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Published Work

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1.    Horton, A.; Nash, K.; Tackie-Yarboi, E.; Kostrevski, A.; Novak, A.; Raghavan, A.; Tulsulkar, J.; Alhadidi, Q.;  Wamer, N.; Langenderfer, B.; Royster, K.; Ducharme, M.; Hagood, K.; Post, M.; Shah, Z. A.; Schiefer, I. T. Furoxans (Oxadiazole-4N-oxides) with Attenuated Reactivity are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory. Journal of Medicinal Chemistry, 2018; 61(10), 4593-4607.

2.    Schiefer, I.; Shah, Z.; inventors; The University of Toledo, USA. assignee. Furoxans as therapies for neurodegenerative disorders; 2018, WO2018093762A1.

3.    Nash, K. M.; Schiefer, I. T.*; Shah, Z.A.* Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke. Free Radicals in Biology and Medicine, 2018; 115: 395-404. *denotes co-corresponding authors

4.    Nash, K. M.; Schiefer, I.; Shah, Z.; inventors; The University of Toledo, USA. assignee. Development of a Class of Reactive Oxygen Species-Sensitive Nitric Oxide Synthase Inhibitors for the Treatment of Ischemic Stroke; 2018, filed, awaiting designation.

5.    Kurogi, K.; Yoshihama, M.; Horton, A.; Schiefer, I. T.; Krasowski, M. D.; Hagey, L. R.; Williams, F. E.; Sakakibara, Y.; Kenmochi, N.; Suiko, M.; Liu, M.  Identification and characterization of 5α-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the zebrafish (Danio rerio).  Journal of Steroid Biochemistry and Molecular Biology, 2017, 174, 120-127.

6.    Alasmari, F.; Crotty Alexander, L. E.; Nelson, J. A.; Schiefer, I. T.; Breen, E.; Drummond, C. A.; Sari, Y. Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017, 77, 1-8.

7.    Yamamoto A., Kurogi K., Schiefer I. T., Liu M., Sakakibara Y., Suiko M., et al. Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan. Biological & Pharmaceutical Bulletin 2016; 39(9):1432-6.

8.    Fà, M.; Zhang, H.; Staniszewski , A.; Saeed, F.;  Shen, L. W.; Schiefer, I. T., Siklos, M.; Tapadar, S.; Litosh, V.; Libien, J.; Petukhov, P.; Teich, A. F.;  Thatcher, G. R. J.; Arancio, O. Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer’s Disease. Journal of Alzheimer’s Disease 2016, 49, 707-721.

9.    Novel cysteine protease inhibitors and uses. Arancio, Ottavio; Fa, Mauro; Schiefer, Isaac T.; Thatcher, Gregory; inventors, 2015, WO2015 US24364 20130201.

10.    Trippier, P. C.; Zhao, K. T.; Fox, S.; Schiefer, I. T.;  Benmohamed, R.; Moran, J.; Kirsch, D. R.; Morimoto, R. I.; Silverman, R. B. Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis. ACS Chemical Neuroscience 2014, 5 (9), 823-829.

11.    Schiefer, I. T.; Tapadar, S.; Litosh, V.; Siklos, M.; Scism, R.; Wijewickrama, G. T.; Chandrasena, E. P.; Sinha, V.; Tavassoli, E.; Brunsteiner, M.; Fa’, M.; Arancio, O.; Petukhov, P.; Thatcher, G. R. J. Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors. Journal of Medicinal Chemistry 2013, 56, 6054–68.

12.    Schiefer, I. T.; VandeVrede, L.; Fa`, M.; Arancio, O.; Thatcher, G. R. J. Furoxans (1,2,5-Oxadiazole- N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents. Journal of Medicinal Chemistry 2012, 55 (7), 3076-3087.

13.    Schiefer, I. T.; Abdul-Hay, S.; Wang, H.; Vanni, M.; Qin, Z.; Thatcher, G. R. Inhibition of Amyloidogenesis by Nonsteroidal Anti-inflammatory Drugs and Their Hybrid Nitrates. Journal of Medicinal Chemistry 2011, 54 (7), 2293-2306.

14.    Abdul-Hay, S.; Schiefer, I. T.; Chandrasena, R. E. P.; Li, M.; Abdelhamid, R.; Wang, Y.-T.; Tavassoli, E.; Michalsen, B.; Asghodom, R. T.; Luo, J.; Thatcher, G. R. J. NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. ACS Medicinal Chemistry Letters 2011, 2 (9), 656-661.

15.    Abdelhamid, R.; Luo, J.; VandeVrede, L.; Kundu, I.; Michalsen, B.; Litosh, V. A.; Schiefer, I. T.; Gherezghiher, T.; Yao, P.; Qin, Z.; Thatcher, G. R. J. Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a Novel GPR30-Dependent Mechanism. ACS Chemical Neuroscience 2011, 2 (5), 256-268.

16.    Anand, S.; Schiefer, I. T.; Thatcher, G. R. Nitric Oxide Donors and Mimetic Molecules in Cancer Chemotherapy and Chemoprevention. Forum on Immunopathological Disease Therapies 2010, 1, 251- 279.

17.    Sinha, V.; Wijewickrama, G. T.; Chandrasena, R. E.; Xu, H.; Edirisinghe, P. D.; Schiefer, I. T.; Thatcher, G. R. Proteomic and Mass Spectroscopic Quantitation of Protein S-nitrosation Differentiates NO-donors. ACS Chemical Biology 2010, 5, 667-680.[1]


 

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